MinireviewDynamic Multiphosphorylation Passwords for Activity - Dependent Gene Expression

long-lasting Ser133 phosphorylation, suggesting the imSynapse-to-nucleus signaling leading to CREB-mediportance of the time integral of phospho-CREB. Possible ated transcription is important for neuronal plasticity. additional regulatory factors include the adaptors linking Nuclear CREB phosphorylation at Ser133 allows converCREB to the basal transcription complex, including the gence of multiple kinase pathways driven by neuronal potential coactivators CREB binding protein (CBP) and activity and links them to transcriptional activation. But, p300. The importance of CBP in PKA-dependent CREB can various pathways share a common effector mechfunction has been demonstrated by several groups, and anism (phosphorylating Ser133) while generating disit is important to note that humans with a mutated CBP tinct patterns of gene expression? We review three allele suffer from mental retardation, among other abNeuron articles that highlight novel ways Ca2 signals normalities (Rubinstein-Taybi Syndrome). can trigger multiple phosphorylation events working With increasingly close scrutiny of CBP, it has become in combination to control CREB and its interaction clear that CBP can itself be actively regulated and could with coactivator molecules. represent more than a mere passive link to the transcrip-